🤷Hirsutism – the appearance in a woman in androgen-sensitive areas, such as the upper lip, chest, inner thighs, back and abdomen, an excessive number of mature hairs that form male-pattern hair
Hirsutism progresses slowly, usually the onset of its manifestations occurs in adolescence.
❗ rapid progression of hirsutism – should cause alertness, most often the cause is an androgen-secreting tumor
Most often, hirsutism accompanies polycystic ovary syndrome (PCOS), is rarely a symptom of other diseases of the endocrine system (Cushing’s syndrome, Congenital dysfunction of the adrenal cortex), and less often a symptom of an androgen-secreting neoplasm.
Hirsutism depends on the sensitivity of hair follicles to androgens and https://pillintrip.com/de/medicine/frontin, where
▶ ️ Under the action of the enzyme 5α-reductase, testosterone is converted into the potent dihydrotestosterone (DHT). ▶ ️DHT, by binding to the androgen receptor, in androgen-sensitive areas of the skin can cause irreversible transformation of primary hair (vellus) into final hair (terminal) – which are thicker, longer and more intensely saturated with pigment. ❗ With an increased activity of the enzyme, those cases are associated when hirsutism is not accompanied by an increase in the level of testosterone or other androgens in the blood serum. 📛 In the case of hirsutism that occurs without an increased level of androgens in the blood and without other symptoms of androgenization (hirsutism of unknown etiology, idiopathic), it is proposed to diagnose the so-called cutaneous hyperandrogenism, in which there is an increased effect of androgens on the hair follicle, although the concentration of testosterone (total and free) in serum never exceeds the upper limit of reference values. ❗Routine determination of androgenic steroids other than testosterone has proven useless in most of these cases. However, the simultaneous presence of other symptoms of hyperandrogenism, especially irregular menstruation, increases the likelihood that even mild hirsutism is accompanied by an increase in androgens.